[contentuser]

Signs and Symptoms


Epidermolysis bullosa simplex can be seen both as a localized or generalized variant. When localized, it affects the palms and soles, and usually presents in adolescence or early adulthood. It may not manifest until the skin is subjected to a high degree of friction, such as with athletic or military training. Excessive sweating often is present.

Generalized epidermolysis bullosa simplex usually occurs at birth or in early infancy, with blisters most commonly on the ha...Read the full article